(5-Fluoro-2-methoxypyridin-4-yl)boronic acid → HCID 178487653, 화합물

HRID 579064

반응식

HRID 579064 반응식
Br[C:2]1[CH:3]=[N:4][N:5]([C:9]2[CH:24]=[CH:23][C:12]([C:13]([NH:15][CH2:16][CH:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[O:14])=[CH:11][N:10]=2)[C:6]=1[O:7]C.[F:25][C:26]1[C:27](B(O)O)=[CH:28][C:29]([O:32][CH3:33])=[N:30][CH:31]=1>>[F:25][C:26]1[C:27]([C:2]2[CH:3]=[N:4][N:5]([C:9]3[CH:24]=[CH:23][C:12]([C:13]([NH:15][CH2:16][CH:17]4[CH2:22][CH2:21][O:20][CH2:19][CH2:18]4)=[O:14])=[CH:11][N:10]=3)[C:6]=2[OH:7])=[CH:28][C:29]([O:32][CH3:33])=[N:30][CH:31]=1

참가 물질

3

반응물 2

HCID 44754837(5-Fluoro-2-methoxypyridin-4-yl)boronic acidHCID 1176002516-(4-bromo-5-methoxy-1H-pyrazol-1-yl)-N-((tetrahydro-2H-pyran-4-yl)methyl)nicotinamide

생성물 1

HCID 178487653HCID 178487653, 화합물

실험 절차

The title compound was prepared in a manner similar to Example 213 using 6-(4-bromo-5-methoxy-1H-pyrazol-1-yl)-N-((tetrahydro-2H-pyran-4-yl)methyl)nicotinamide (60.0 mg, 0.152 mmol), (5-fluoro-2-methoxypyridin-4-yl)boronic acid. 1H NMR (400 MHz, DMSO-d6) δ 1.15 (qd, J=12.3, 4.4 Hz, 2 H) 1.55 (d, J=12.9 Hz, 2 H) 1.74 (ddt, J=11.1, 7.4, 3.9, 3.9 Hz, 1 H) 3.13 (t, J=6.3 Hz, 2 H) 3.74-3.82 (m, 5 H) 7.74 (d, J=4.8 Hz, 1 H) 8.03 (d, J=3.0 Hz, 1 H) 8.16 (d, J=2.5 Hz, 1 H 8.30-8.45 (m, 2 H) 8.66 (t, J=5.7 Hz, 1 H) 8.84 (d, J=1.3 Hz, 1 H). MS m/z [M+H]+ 428.5.

출처 및 근거

ORD 기록
ord-00c83ef435fb4ffe9bd6ff435e089ef2
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09040522B2

연결된 노트

불러오는 중…