Benzaldehyde → 1-[2-(2,6-Diethyl-4-methylphenyl)-2-oxoacetyl]-2-(phenylmethylidene)hydrazine

HRID 579281노트

반응식

HRID 579281 반응식
[CH2:1]([C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[C:5]([CH2:10][CH3:11])[C:4]=1[C:12](=[O:17])[C:13]([NH:15][NH2:16])=[O:14])[CH3:2].[CH:18](=O)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>C1(C)C=CC=CC=1>[CH2:1]([C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[C:5]([CH2:10][CH3:11])[C:4]=1[C:12](=[O:17])[C:13]([NH:15][N:16]=[CH:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:14])[CH3:2]

참가 물질

4

반응물 2

HCID 240BenzaldehydeHCID 569428732-(2,6-Diethyl-4-methylphenyl)-2-oxoacetohydrazide

생성물 1

HCID 666919781-[2-(2,6-Diethyl-4-methylphenyl)-2-oxoacetyl]-2-(phenylmethylidene)hydrazine수율 96.9%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a 100 mL volume three-necked flask with Dean-Stark, 9.38 g of 2-(2,6-diethyl-4-methylphenyl)-2-oxoacetohydrazide ((12-1)-(11)-39), 32 ml of toluene and 4.51 g of benzaldehyde were added under a nitrogen atmosphere, and the mixture was subjected to azeotropic dehydration under 100 mmHg at 50° C. for 2 hours. The reaction mixture was concentrated under reduced pressure to give 12.51 g of 1-[2-(2,6-diethyl-4-methylphenyl)-2-oxoacetyl]-2-(phenylmethylidene)hydrazine ((40-a)-(14)-6).

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-566cdde4d3ad41b997f31885b8dd4f9f
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09040709B2

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