Dimethylamine → 1-(2-Chlorophenyl)-N,N-dimethylmethanamine

HRID 579420노트

반응식

HRID 579420 반응식
[CH3:1][NH:2][CH3:3].[Cl:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH2:7]Cl>O>[Cl:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH2:7][N:2]([CH3:3])[CH3:1]

참가 물질

4

반응물 2

HCID 674DimethylamineHCID 119062-Chlorobenzyl chloride

생성물 1

HCID 8180141-(2-Chlorophenyl)-N,N-dimethylmethanamine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The dimethylamine and water streams were initially combined and preheated to 130° C. The stream of o-chlorobenzyl chloride was then introduced by way of a mixing chamber. The temperature in the reaction tube was set to approximately 140° C. After running through the reaction zone, the mixture was cooled and depressurized. The workup analogous to example 1 afforded the (2-chlorobenzyl)dimethylamine target product with a yield and purity as in example 3.

후처리

  1. custompreheated to 130° C
  2. customwas set to approximately 140° C
  3. temperaturethe mixture was cooled

출처 및 근거

ORD 기록
ord-1ce7e88ae1444bdba8d0e8770aacc4b8
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09040751B2

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