Diethyl Ether → 2-(7-Hydroxy-2-oxo-2H-chromen-3-yl)-4-methyl-thiazole-5-carboxylic acid

HRID 579440노트

반응식

HRID 579440 반응식
C([O:5][C:6]([C:8]1[S:12][C:11]([C:13]2[C:14](=[O:24])[O:15][C:16]3[C:21]([CH:22]=2)=[CH:20][CH:19]=[C:18]([OH:23])[CH:17]=3)=[N:10][C:9]=1[CH3:25])=[O:7])(C)(C)C.C1(OC)C=CC=CC=1.FC(F)(F)C(O)=O.C(OCC)C>ClCCl>[OH:23][C:18]1[CH:17]=[C:16]2[C:21]([CH:22]=[C:13]([C:11]3[S:12][C:8]([C:6]([OH:7])=[O:5])=[C:9]([CH3:25])[N:10]=3)[C:14](=[O:24])[O:15]2)=[CH:20][CH:19]=1

참가 물질

6

반응물 4

HCID 3283Diethyl EtherHCID 6422Trifluoroacetic acidHCID 7519AnisoleHCID 1363877692-(7-Hydroxy-2-oxo-2H-chromen-3-yl)-4-methyl-thiazole-5-carboxylic acid tert-butyl ester

생성물 1

HCID 1363877702-(7-Hydroxy-2-oxo-2H-chromen-3-yl)-4-methyl-thiazole-5-carboxylic acid수율 87%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a suspension of 2-(7-hydroxy-2-oxo-2H-chromen-3-yl)-4-methyl-thiazole-5-carboxylic acid tert-butyl ester (387 mg, 1.08 mmol) and anisole (117 μL, 117 mg, 1.08 mmol) in anhydrous dichloromethane (5 mL) was added trifluoroacetic acid (5 mL) and the obtained solution was stirred at room temperature for 6 h. Diethyl ether (30 mL) was added, the precipitate was collected, washed with diethyl ether and dried in air. In this manner the title compound (285 mg, 0.94 mmol, 87%) was obtained as a light brown solid.

후처리

  1. customthe precipitate was collected
  2. washwashed with diethyl ether
  3. customdried in air

출처 및 근거

ORD 기록
ord-92a337548f80445897935269cabf3ad4
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09040714B2

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