Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → 6-Hydroxy-2-oxo-1,2-dihydroquinoline-5-carbaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Trifluoroacetic anhydride | HCID 9845 | — |
| 반응물 | 3-Bromo-7-hydroxy-4-methylchromen-2-one | HCID 5337545 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 6-Hydroxy-2-oxo-1,2-dihydroquinoline-5-carbaldehyde | HCID 86683429 | 95.3% |
반응 단계
Compound 1 (38 g, 249.6 mmol) and pyridine (21.7 g, 275.0 mmol) were dissolved in DCM (750 mL). (CF3CO)2O (57.7 g, 275.0 mmol) was added dropwise at 0° C. After that the reaction mixture was stirred at RT for 16 h. The reaction mixture was diluted with DCM (500 mL), washed with 1N HCl, concentrated. The residue was purified by silica gel column (PE:EA=10:1), afforded compound 2 (45 g, 72%) as white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09040714B2 |
| 출처 데이터셋 | uspto-grants-2015_05 |
| ORD ID | ord-e66b7c0178974a83b40a588fcf4809cb |
| 출처 메모 | uspto-grants-2015_05 |