Ammonia → 6-[4-(4-Oxo-1,4-dihydropyridin-1-yl)phenyl]-4,5-dihydro-3(2H)-pyridazinone

HRID 5797

반응식

HRID 5797 반응식
Cl.[NH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH2:10][CH2:11][C:12](=[O:15])[NH:13][N:14]=2)=[CH:5][CH:4]=1.O1[CH:21]=[CH:20][C:19](=[O:22])[CH:18]=[CH:17]1.N>O>[O:22]=[C:19]1[CH:20]=[CH:21][N:2]([C:3]2[CH:8]=[CH:7][C:6]([C:9]3[CH2:10][CH2:11][C:12](=[O:15])[NH:13][N:14]=3)=[CH:5][CH:4]=2)[CH:17]=[CH:18]1

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 79684H-pyran-4-oneHCID 128050056-(4-aminophenyl)-4,5-dihydro-3(2H)-pyridazinone hydrochloride

생성물 1

HCID 197942256-[4-(4-Oxo-1,4-dihydropyridin-1-yl)phenyl]-4,5-dihydro-3(2H)-pyridazinone

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

A stirred mixture of 6-(4-aminophenyl)-4,5-dihydro-3(2H)-pyridazinone hydrochloride (1.5 g), 4H-pyran-4-one (0.7 g), and water (20 ml), was heated under reflux for 41/2 hours. The resultant solid was dissolved in the minimum of hot water and the solution was neutralised with ammonia to give the crude product. Recrystallisation from water gave the title compound, 0.73 g, m.p. 270°-272° C.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 41/2 hours
  3. customto give the crude product
  4. customRecrystallisation from water

출처 및 근거

ORD 기록
ord-485e041677a3458f8860e1c73bcd36fb
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05246928

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