Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Iodide → 1-(2-(Benzyloxy)-4-fluorophenyl)ethanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Iodide | HCID 4875 | — |
| 반응물 | Benzyl Chloride | HCID 7503 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4'-Fluoro-2'-hydroxyacetophenone | HCID 2737326 | — |
| 반응물 | N-[(1-acetyl-4-piperidinyl)methyl]-N'-(2-fluorophenyl)thiourea | HCID 21241609 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 2,3-Dihydro-1,4-benzodioxin-6-yl isothiocyanate | HCID 2776173 | — |
| 생성물 | 1-(2-(Benzyloxy)-4-fluorophenyl)ethanone | HCID 21241577 | 58% |
반응 단계
A mixture of 13 parts of 1-(4-fluoro-2-hydroxyphenyl)ethanone, 14.9 parts of (chloromethyl)benzene, 16.4 parts of potassium carbonate, 0.1 parts of potassium iodide and 120 parts of 2-propanone was stirred overnight at reflux temperature. The reaction mixture was evaporated. The reaction mixture was poured into water. The product was extracted three times with trichloromethane. The combined extracts were dried, filtered and evaporated. The residue was crystallized from a mixture of 2-propanol and water. The product was filtered off and dried, yielding 11 parts (58%) of 1-[4-fluoro-2-(phenylmethoxy)phenyl]ethanone (intermediate 76).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04749702 |
| 출처 데이터셋 | uspto-grants-1988_06 |
| ORD ID | ord-999acce87e7e48318b5901a2eb848d87 |
| 출처 메모 | uspto-grants-1988_06 |