N,N'-Dimethylethylenediamine → tert-butyl 4-(3-bromo-6-(6-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)-1H-pyrazolo[4,3-c]pyridin-1-yl)pyridin-2-yl)-6-hydroxy-1,4-diazepane-1-carboxylate

반응식

[F:1][C:2]([F:19])([F:18])[CH2:3][N:4]1[CH:8]=[C:7]([C:9]2[N:14]=[CH:13][C:12]3[CH:15]=[N:16][NH:17][C:11]=3[CH:10]=2)[CH:6]=[N:5]1.[Br:20][C:21]1[C:22]([N:28]2[CH2:34][CH:33]([OH:35])[CH2:32][N:31]([C:36]([O:38][C:39]([CH3:42])([CH3:41])[CH3:40])=[O:37])[CH2:30][CH2:29]2)=[N:23][C:24](I)=[CH:25][CH:26]=1.CNCCNC.C([O-])([O-])=O.[K+].[K+]>O1CCOCC1.[Cu]I>[Br:20][C:21]1[C:22]([N:28]2[CH2:34][CH:33]([OH:35])[CH2:32][N:31]([C:36]([O:38][C:39]([CH3:42])([CH3:41])[CH3:40])=[O:37])[CH2:30][CH2:29]2)=[N:23][C:24]([N:17]2[C:11]3[CH:10]=[C:9]([C:7]4[CH:6]=[N:5][N:4]([CH2:3][C:2]([F:1])([F:18])[F:19])[CH:8]=4)[N:14]=[CH:13][C:12]=3[CH:15]=[N:16]2)=[CH:25][CH:26]=1