Methanol → AC-Pro-ome

HRID 579824

반응식

HRID 579824 반응식
CC1C=CC=C(C)C=1C.C[OH:11].[C:12]([N:15]1[CH2:19][CH2:18][CH:17]=[CH:16]1)(=[O:14])[CH3:13].[O:20]1[CH2:24]CC[CH2:21]1>Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[CH3:21][O:20][C:24](=[O:11])[C@@H:16]1[CH2:17][CH2:18][CH2:19][N:15]1[C:12](=[O:14])[CH3:13]

참가 물질

6

반응물 4

HCID 887MethanolHCID 8028TetrahydrofuranHCID 106861,2,3-TrimethylbenzeneHCID 10909522N-Acetyl-2-pyrroline2회

생성물 1

HCID 11019314AC-Pro-ome수율 47.9%

시약·촉매·용매 1

HCID 178418476HCID 178418476, 화합물촉매

반응 조건

온도
100 °C

실험 절차

A 70 mL stainless steel high pressure reactor having a Pyrex glass liner and a magnetic stir bar was charged with 5 mL of tetrahydrofuran, 0.5 mmol of 1,2,3-trimethylbenzene internal standard, 0.6 mmol of CH3OH, 35.1 mg of (PPh3)2PdCl2, and 55.5 mg of N-acetyl-2-pyrroline. The reactor ws pressurized to 1000 psi with CO at room temperature, and the reaction mixture was stirred for 44.25 hours at 100° C. Thereafter, the reactor was cooled to room temperature and vented to atmospheric pressure. The product mixture was analyzed by gas chromatography and mass spectroscopy, and the analysis indicated complete conversion of N-acetyl-2-pyrroline and a 47.9% yield of N-acetylproline methyl ester.

후처리

  1. customA 70 mL stainless steel high pressure reactor having
  2. customws pressurized to 1000 psi with CO at room temperature
  3. temperatureThereafter, the reactor was cooled to room temperature

출처 및 근거

ORD 기록
ord-db92a17fba884a99a405b18ab16d2606
출처 데이터셋
uspto-grants-1988_06
특허 번호
US04749786

연결된 노트

불러오는 중…