Methanol → AC-Pro-ome

HRID 579825

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HRID 579825 반응식
C[OH:2].[C:3]([N:6]1[CH2:10][CH2:9][CH:8]=[CH:7]1)(=[O:5])[CH3:4].[O:11]1[CH2:15]CC[CH2:12]1>Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[CH3:12][O:11][C:15](=[O:2])[C@@H:7]1[CH2:8][CH2:9][CH2:10][N:6]1[C:3](=[O:5])[CH3:4]

참가 물질

5

반응물 3

HCID 887MethanolHCID 8028TetrahydrofuranHCID 10909522N-Acetyl-2-pyrroline2회

생성물 1

HCID 11019314AC-Pro-ome수율 42.8%

시약·촉매·용매 1

HCID 178418476HCID 178418476, 화합물촉매

반응 조건

온도
100 °C

실험 절차

A 70 mL stainless steel high pressure reactor having a Pyrex glass liner and a magnetic stir bar was charged with 5 mL of tetrahydrofuran, 0.5 mmol of n-pendadecane internal standard, 0.5 mmol of CH3OH, 35.1 mg of (PPh3)2PdCl2, and 56.6 mg of N-acetyl-2-pyrroline. The reactor was pressurized to 1000 psi with CO at room temperature, and the reaction mixture was stirred at 100° C. for 26 hours. Thereafter, the reactor was cooled to room temperature and vented to atmospheric pressure. The product mixture was analyzed by gas chromatography, and the analysis indicated 98.4% conversion of N-acetyl-2-pyrroline and 42.8% yield of N-acetylproline methyl ester.

후처리

  1. customA 70 mL stainless steel high pressure reactor having
  2. customwas pressurized to 1000 psi with CO at room temperature
  3. temperatureThereafter, the reactor was cooled to room temperature

출처 및 근거

ORD 기록
ord-23c5847cc75b4d75b1676b3af4447543
출처 데이터셋
uspto-grants-1988_06
특허 번호
US04749786

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