Methanol → AC-Pro-ome

HRID 579828

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HRID 579828 반응식
CCCCCCCCCCCCCCC.C[OH:17].[C:18]([N:21]1[CH2:25][CH2:24][CH:23]=[CH:22]1)(=[O:20])[CH3:19].[O:26]1[CH2:30]CC[CH2:27]1>Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[CH3:27][O:26][C:30](=[O:17])[C@@H:22]1[CH2:23][CH2:24][CH2:25][N:21]1[C:18](=[O:20])[CH3:19]

참가 물질

6

반응물 4

HCID 887MethanolHCID 8028TetrahydrofuranHCID 12391PentadecaneHCID 10909522N-Acetyl-2-pyrroline2회

생성물 1

HCID 11019314AC-Pro-ome수율 25.2%

시약·촉매·용매 1

HCID 178418476HCID 178418476, 화합물촉매

반응 조건

온도
100 °C

실험 절차

A 70 mL stainless steel high pressure reactor having a Pyrex glass liner and a magnetic stir bar was charged with 5 mL of tetrahydrofuran, 0.5 mmol of n-pentadecane internal standard, 0.75 mmol of CH3OH, 56.8 mg of (PPh3)2PdCl2, and 72.35 mg of N-acetyl-2-pyrroline. The reactor was pressurized with 1000 psi of CO and 300 psi of H2 at room temperature, and the reaction mixture was stirred at 100° C. for 18 hours. Thereafter, the reactor was cooled to room temperature and vented to atmospheric pressure. The product mixture was analyzed by gas chromatography, and the analysis indicated 100% conversion of N-acetyl-2-pyrroline and 25.2% yield of N-acetylproline methyl ester.

후처리

  1. customA 70 mL stainless steel high pressure reactor having
  2. customwas pressurized with 1000 psi of CO and 300 psi of H2 at room temperature
  3. temperatureThereafter, the reactor was cooled to room temperature

출처 및 근거

ORD 기록
ord-393971dd9a944e91b90cd4b696449cac
출처 데이터셋
uspto-grants-1988_06
특허 번호
US04749786

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