Hydrogen Sulfide → 4,6-Dimethylpyrimidin-2-ylthiourea

HRID 579903

반응식

HRID 579903 반응식
[C:1]([NH:3][C:4]1[N:9]=[C:8]([CH3:10])[CH:7]=[C:6]([CH3:11])[N:5]=1)#[N:2].[SH2:12].C(Cl)Cl>N1C=CC=CC=1>[CH3:10][C:8]1[CH:7]=[C:6]([CH3:11])[N:5]=[C:4]([NH:3][C:1]([NH2:2])=[S:12])[N:9]=1

참가 물질

5

반응물 3

HCID 402Hydrogen Sulfide2회HCID 6344DichloromethaneHCID 521618(4,6-Dimethylpyrimidin-2-yl)cyanamide

생성물 1

HCID 7475004,6-Dimethylpyrimidin-2-ylthiourea

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A suspension of 10 g of 2-cyanoamino-4,6-dimethylpyrimidine in 50 ml of pyridine was saturated with hydrogen sulfide and stored for 1 hour at 25°. The H2S treatment was repeated twice more, and the mixture was allowed to stir at 25° for 16 hours. Methylene chloride was added, and the product was filtered and washed with methylene chloride to afford 8 g of 4,6-dimethylpyrimidin-2-yl thiourea, m.p. >260°. IR (Nujol) 3280, 3180, 3120, 1610 cm-1.

후처리

  1. filtrationthe product was filtered
  2. washwashed with methylene chloride

출처 및 근거

ORD 기록
ord-2917e0a39b774850b396f72ca94bf80d
출처 데이터셋
uspto-grants-1988_06
특허 번호
US04750930

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