참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | 3-Nitrophenylacetic acid | HCID 15876 | — |
| 반응물 | (Dimethyl sulfide)trihydroboron | HCID 12423031 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | alpha-Methyl-3-nitrobenzenemethanol | HCID 223135 | — |
반응 단계
40 g of 3-nitrophenylacetic acid was added to a solution of 26 ml of 10M borane-methyl sulfide in 200 ml of THF, and the mixture was stirred at 25° C. for 3 hr. The solution was then acidified with HCl in methanol, followed by evaporation of the solvent. The product 3-nitrophenylethanol (IV, A=H) was partitioned between diethyl ether (Et2O) and aqueous sodium carbonate, and the Et2O layer dried over sodium sulfate. Evaporation of the Et2O afforded 34.8 g of 3-nitrophenylethanol (IV, A=H) as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04752621 |
|---|
| 출처 데이터셋 | uspto-grants-1988_06 |
|---|
| ORD ID | ord-d72bb97780a14745b1520b0bee87dcf0 |
|---|
| 출처 메모 | uspto-grants-1988_06 |
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