Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 2-(5-bromo-3-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Bromoacetamide | HCID 69632 | — |
| 반응물 | 1-Methyl-5-bromouracil | HCID 73276 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | 2-(5-bromo-3-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)acetamide | HCID 89781766 | — |
반응 단계
A mixture of 5-bromo-1-methylpyrimidine-2,4(1H,3H)-dione (200 mg, 0.976 mmol), 2-bromoacetamide (162 mg, 1.171 mmol) and K2CO3 (162 mg, 1.171 mmol) in DMSO (4 mL) was stirred at room temperature for 4 hours. The reaction mixture was subsequently filtered and purified via preparative HPLC, eluting with a gradient of 1-40% ACN (containing 0.035% TFA) in H2O (containing 0.05% TFA) to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09434743B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-55ff6c7d81534e98b295d92b9e624b09 |
| 출처 메모 | uspto-grants-2016_09 |