8-Amino-2-naphthalenol → n-(7-Hydroxynaphthalen-1-yl)formamide

HRID 580438노트

반응식

HRID 580438 반응식
[NH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[CH:10]=[C:9]([OH:12])[CH:8]=[CH:7]2.[C:13](OC(=O)C)(=[O:15])C.C(O)=O>>[CH:13]([NH:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[CH:10]=[C:9]([OH:12])[CH:8]=[CH:7]2)=[O:15]

참가 물질

3

반응물 2

HCID 83588-Amino-2-naphthalenolHCID 19869020Acetic anhydride formic acid

생성물 1

HCID 244439n-(7-Hydroxynaphthalen-1-yl)formamide

반응 조건

온도
50 °C

실험 절차

Ten grams of 8-amino-2-naphthol were added to a mixture of acetic anhydride/formic acid (40 mL:20 mL). The mixture was warmed at 50° C. for one hour and then quenched on ice. After stirring for some time, the product solidified and was filtered off. Recrystallization from ethanol gave 6 g of 8-formamido-2-naphthol melting at 203°-205° C.

후처리

  1. customquenched on ice
  2. filtrationwas filtered off
  3. customRecrystallization from ethanol

출처 및 근거

ORD 기록
ord-402682e39859488ca790276b1fbdf26b
출처 데이터셋
uspto-grants-1988_06
특허 번호
US04753922

반응 노트

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