Isatoic Anhydride → 2-Amino-N-[4-(1H-imidazol-1-yl)butyl]benzamide

HRID 580464노트

반응식

HRID 580464 반응식
[C:1]12[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=1)[NH:6]C(=O)[O:4][C:2]2=O.[N:13]1([CH2:18][CH2:19][CH2:20][CH2:21][NH2:22])[CH:17]=[CH:16][N:15]=[CH:14]1>C(O)C>[NH2:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:1]=1[C:2]([NH:22][CH2:21][CH2:20][CH2:19][CH2:18][N:13]1[CH:17]=[CH:16][N:15]=[CH:14]1)=[O:4]

참가 물질

4

반응물 2

HCID 8359Isatoic AnhydrideHCID 43794804-(1H-imidazol-1-yl)butan-1-amine

생성물 1

HCID 139527342-Amino-N-[4-(1H-imidazol-1-yl)butyl]benzamide

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 1.63 g of isatoic anhydride, 1.39 g of 1H-imidazole-1-butanamine and 25 ml of ethanol was stirred at room temperature for 22 hours. The reaction mixture was concentrated and the residue was dissolved in ethyl acetate and cooled. The desired product was isolated by filtration, mp 91°14 93° C.

후처리

  1. concentrationThe reaction mixture was concentrated
  2. dissolutionthe residue was dissolved in ethyl acetate
  3. temperaturecooled

출처 및 근거

ORD 기록
ord-a2664955ec9f4ae7943c5f76078d3435
출처 데이터셋
uspto-grants-1988_06
특허 번호
US04753944

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