Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → N-(7-methoxy-1,8-naphthyridin2-yl)-3-acetoxybenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | 3-(Chlorocarbonyl)phenyl acetate | HCID 12998558 | — |
| 반응물 | 7-methoxy-1,8-Naphthyridin-2-amine | HCID 21793027 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | N-(7-methoxy-1,8-naphthyridin2-yl)-3-acetoxybenzamide | HCID 13983395 | 78.6% |
반응 단계
The procedure is similar to that described in Example 3, but starting with 2-amino-7-methoxynaphthyridine (3.5 g), 3-acetoxybenzoyl chloride (4.4 g) and anhydrous pyridine (40 cc). The reaction mixture is poured into water (400 cc) and the precipitate obtained is separated by filtration and then washed with water (6×100 cc) and dried in the air. On recrystallization from ethanol (140 cc) of the product thereby obtained, N-(7-methoxy-1,8-naphthyridin2-yl)-3-acetoxybenzamide (5.3 g), m.p. 172° C., is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04753941 |
| 출처 데이터셋 | uspto-grants-1988_06 |
| ORD ID | ord-2e02604d1e1447bfb7a6e3d9f54c6d2c |
| 출처 메모 | uspto-grants-1988_06 |