Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
7-Chloro-1,8-naphthyridin-2-amine → HCID 13983407, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 7-Chloro-1,8-naphthyridin-2-amine | HCID 85199 | — |
| 반응물 | 4-Thiazolecarboxylic acid | HCID 304271 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | HCID 13983407 | HCID 13983407 | 77.2% |
반응 단계
The procedure is similar to that described in Example 2, but starting with 4-thiazolecarboxylic acid (4.8 g), N,N'-carbonyldiimidazole (7.5 g) and 2-amino-7-chloro-1,8-naphthyridine (4.8 g). The product obtained by precipitation in water is purified by recrystallization in dimethylformamide (350 cc). N-(7-Chloro-1,8-naphthyridin-2-yl)-4-thiazolecarboxamide (6 g), m.p. 325° C., is thereby obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04753941 |
| 출처 데이터셋 | uspto-grants-1988_06 |
| ORD ID | ord-f0e5d4ae00d04eab8b097595cd343e10 |
| 출처 메모 | uspto-grants-1988_06 |