Ammonium Hydroxide → 5-Bromopyridine-2-sulfonamide

반응식

Cl.[Br:2][C:3]1[CH:4]=[CH:5][C:6]([S:9](Cl)(=[O:11])=[O:10])=[N:7][CH:8]=1.[OH-].[NH4+:14]>>[Br:2][C:3]1[CH:4]=[CH:5][C:6]([S:9]([NH2:14])(=[O:11])=[O:10])=[N:7][CH:8]=1

참가 물질

반응물 2

HCID 14923Ammonium Hydroxide

HCID 467388875-Bromopyridine-2-sulfonyl chloride, HCl

생성물 1

HCID 509897865-Bromopyridine-2-sulfonamide

반응 조건

온도: 70 °C

실험 절차

To a 4 mL vial equipped with a magnetic stir bar were added 5-bromopyridine-2-sulfonyl chloride hydrochloride (250 mg, 0.853 mmol) and ammonium hydroxide (1329 μL, 34.1 mmol) to give a white suspension, which was heated to 70° C. in a sand bath overnight. The solvent was subsequently evaporated to give the title compound, which was used without further purification.

후처리

customTo a 4 mL vial equipped with a magnetic stir bar
customto give a white suspension, which
customThe solvent was subsequently evaporated

출처 및 근거

ORD 기록: ord-079c2d860f624468a24d1ac13482ea9b
출처 데이터셋: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09434743B2

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