1,3-Dimethyl-5-ethoxycarbonylbarbituric acid → 1,3-Dimethyl-5-[4-(2-isopropyl-6-methylpyrimidin-4-yloxy)phenylcarbamoyl]barbituric acid

HRID 580538노트

반응식

HRID 580538 반응식
[CH3:1][N:2]1[C:9](=[O:10])[CH:8]([C:11]([O:13]CC)=O)[C:6](=[O:7])[N:5]([CH3:16])[C:3]1=[O:4].[CH:17]([C:20]1[N:25]=[C:24]([O:26][C:27]2[CH:33]=[CH:32][C:30]([NH2:31])=[CH:29][CH:28]=2)[CH:23]=[C:22]([CH3:34])[N:21]=1)([CH3:19])[CH3:18]>C1(C)C=CC=CC=1>[CH3:16][N:5]1[C:6](=[O:7])[CH:8]([C:11](=[O:13])[NH:31][C:30]2[CH:29]=[CH:28][C:27]([O:26][C:24]3[CH:23]=[C:22]([CH3:34])[N:21]=[C:20]([CH:17]([CH3:19])[CH3:18])[N:25]=3)=[CH:33][CH:32]=2)[C:9](=[O:10])[N:2]([CH3:1])[C:3]1=[O:4]

참가 물질

4

반응물 2

HCID 5937141,3-Dimethyl-5-ethoxycarbonylbarbituric acidHCID 20133966HCID 20133966, 화합물

생성물 1

HCID 201339651,3-Dimethyl-5-[4-(2-isopropyl-6-methylpyrimidin-4-yloxy)phenylcarbamoyl]barbituric acid

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

3.0 g (0.013 mole) of 1,3-dimethyl-5-ethoxycarbonylbarbituric acid and 3.2 g (0.013 mole) of 4-(2-isopropyl-6-methylpyrimidin-4-yloxy)aniline are suspended in 30 ml of toluene and heated for 18 hours at reflux temperature in an inert gas atmosphere (nitrogen). After cooling, the precipitate is isolated by filtration, washed with alcohol and dried.

후처리

  1. temperatureheated for 18 hours
  2. temperatureat reflux temperature in an inert gas atmosphere (nitrogen)
  3. temperatureAfter cooling
  4. customthe precipitate is isolated by filtration
  5. washwashed with alcohol
  6. customdried

출처 및 근거

ORD 기록
ord-974fd465a25540a196a510ec2c481ca6
출처 데이터셋
uspto-grants-1988_06
특허 번호
US04753940

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