Potassium Carbonate → HCID 19525517, 화합물

HRID 58054

반응식

HRID 58054 반응식
[Br:1][C:2]1[C:3]([CH3:8])=[N:4][NH:5][C:6]=1[CH3:7].Br[CH2:10][C:11]([NH:13][CH:14]([CH3:16])[CH3:15])=[O:12].C([O-])([O-])=O.[K+].[K+]>C(#N)C>[Br:1][C:2]1[C:3]([CH3:8])=[N:4][N:5]([CH2:10][C:11]([NH:13][CH:14]([CH3:16])[CH3:15])=[O:12])[C:6]=1[CH3:7]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 769374-bromo-3,5-dimethyl-1H-pyrazoleHCID 125092612-Bromo-N-isopropylacetamide

생성물 1

HCID 19525517HCID 19525517, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
70 °C

실험 절차

To a 4 mL vial equipped with a magnetic stir bar were added 4-bromo-3,5-dimethyl-1H-pyrazole (50 mg, 0.286 mmol), 2-bromo-N-isopropylacetamide (51.4 mg, 0.286 mmol), K2CO3 (118 mg, 0.857 mmol), and acetonitrile (2 mL). The contents of the vial were stirred to give a white suspension. The vial was heated in a sand bath to 70° C. for 24 hours. The reaction mixture was subsequently partitioned between water (10 mL) and ethyl acetate (15 mL). The layers were separated, and the aqueous layer was back-extracted with ethyl acetate (15 mL). The combined organic layers were concentrated to give the title compound as a white solid, which was used without further purification (80 mg).

후처리

  1. customTo a 4 mL vial equipped with a magnetic stir bar
  2. customto give a white suspension
  3. customThe reaction mixture was subsequently partitioned between water (10 mL) and ethyl acetate (15 mL)
  4. customThe layers were separated
  5. extractionthe aqueous layer was back-extracted with ethyl acetate (15 mL)
  6. concentrationThe combined organic layers were concentrated

출처 및 근거

ORD 기록
ord-9b7a6a77cab942a590f5687551911879
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434743B2

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