HCID 70202469, 화합물 → rac-tert-butyl N-[(3R,4S)-4-methylpyrrolidin-3-yl]carbamate
반응식
C([N:8]1[CH2:12][C@@H:11]([CH3:13])[C@H:10]([NH:14][C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:9]1)C1C=CC=CC=1.[H][H]>C(O)C.[Pd]>[C:18]([O:17][C:15]([NH:14][C@H:10]1[C@H:11]([CH3:13])[CH2:12][NH:8][CH2:9]1)=[O:16])([CH3:21])([CH3:19])[CH3:20]참가 물질
5
실험 절차
A suspension of 1-benzyl-trans-3-t-butoxycarbonylamino-4-methylpyrrolidine (4.8 g) and 10% palladium-on-charcoal (1.8 g) in ethanol (40 ml) was shaken with hydrogen were absorbed under elevated pressure (100 kg/cm2) at 50°-70° C. for 6.5 hours. The catalyst was removed by filtration and the filtrate was evaporated to give the title compound (3.09 g) as brown oil. This oil was gradually solidified at room temperature.
후처리
- customwere absorbed under elevated pressure (100 kg/cm2) at 50°-70° C. for 6.5 hours
- customThe catalyst was removed by filtration
- customthe filtrate was evaporated
출처 및 근거
- ORD 기록
- ord-cba856acedb249e185beebb58b31f2d8
- 출처 데이터셋
- uspto-grants-1988_06
- 특허 번호
- US04753953
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