Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,8-Diazabicyclo(5.4.0)undec-7-ene → 7-(3-Aminomethyl-4-methyl-1-pyrrolidinyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| 반응물 | 1-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | HCID 535414 | — |
| 반응물 | (4-Methylpyrrolidin-3-yl)methanamine | HCID 4583498 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 7-(3-Aminomethyl-4-methyl-1-pyrrolidinyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid | HCID 13920560 | 56.3% |
반응 단계
A mixture of 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (0.6 g), anhydrous acetonitrile (5 ml), 3-aminomethyl-4-methylpyrrolidine (0.29 g) and DBU (0.33 g) was refluxed for an hour and then stirred at room temperature for 2 hours and allowed to stand overnight. The resulting precipitate was collected by filtration and recrystallized from chloroform-methanol-concentrated aqueous ammonia (10:10:1) to give the title compound (0.45 g) as colorless prisms, mp 249°-252.5° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04753953 |
| 출처 데이터셋 | uspto-grants-1988_06 |
| ORD ID | ord-da6a715611704ff8a85850b3d8c7e730 |
| 출처 메모 | uspto-grants-1988_06 |