Water → 3-Bromo-4-dimethylaminobenzophenone

HRID 580613

반응식

HRID 580613 반응식
[CH3:1][N:2]([CH3:17])[C:3]1[CH:16]=[CH:15][C:6]([C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[O:8])=[CH:5][CH:4]=1.[Br:18]Br.O.S(=O)(O)[O-].[Na+]>C(O)(=O)C.C1(C)C=CC=CC=1.O>[Br:18][C:4]1[CH:5]=[C:6]([CH:15]=[CH:16][C:3]=1[N:2]([CH3:17])[CH3:1])[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8]

참가 물질

7

반응물 4

HCID 962WaterHCID 107374-(Dimethylamino)benzophenoneHCID 24408BromineHCID 23665763Sodium Bisulfite

생성물 1

HCID 201339243-Bromo-4-dimethylaminobenzophenone

시약·촉매·용매 2

HCID 176Acetic Acid용매2회HCID 22272177Toluene water용매

실험 절차

22.5 g (0.1 mol) of 4-dimethylaminobenzophenone were dissolved in 60 ml of acetic acid, and then a solution of 5.3 ml (0.105 mol) of bromine in 20 ml of acetic acid was added dropwise thereto over a period of one hour, while stirring. The mixture was then stirred for 30 minutes more, and some water and some sodium bisulfite for decolorization were added. The greasy substance thus obtained was shaken with toluene/water, the toluene phase was washed twice more with water and dried, and the toluene was distilled off in vacuo. Yield: 24.4 g (80% of theory); viscous oil.

후처리

  1. stirringThe mixture was then stirred for 30 minutes more
  2. customThe greasy substance thus obtained
  3. washthe toluene phase was washed twice more with water
  4. customdried
  5. distillationthe toluene was distilled off in vacuo

출처 및 근거

ORD 기록
ord-7e7e096c21da4933824590331772f5b7
출처 데이터셋
uspto-grants-1988_06
특허 번호
US04753934

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