Trifluoroacetic acid → 6-Bromo-2-(4-piperidinyl)-1,8-naphthyridine
반응식
C([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:23]=[CH:22][C:21]3[C:16](=[N:17][CH:18]=[C:19]([Br:24])[CH:20]=3)[N:15]=2)[CH2:10][CH2:9]1)(OC(C)(C)C)=O.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Br:24][C:19]1[CH:20]=[C:21]2[C:16](=[N:17][CH:18]=1)[N:15]=[C:14]([CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)[CH:23]=[CH:22]2참가 물질
4
실험 절차
A solution of bromide 3-4 (3.5 g, 8.92 mmol), CH2Cl2 (20 ml) and TFA (10 ml) was stirred for 1.0 h. The reaction was concentrated and then azeotroped with toluene. The residue was dissolved in 1N NaOH and then extracted with CHCl3. The CHCl3 portion was washed with brine, dried (MgSO4) and concentrated providing amine 3-5 as a brown solid.
후처리
- concentrationThe reaction was concentrated
- customazeotroped with toluene
- dissolutionThe residue was dissolved in 1N NaOH
- extractionextracted with CHCl3
- washThe CHCl3 portion was washed with brine
- dry with materialdried (MgSO4)
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-c6d2dd03aec94ef382b84d7c15b896a8
- 출처 데이터셋
- uspto-grants-1999_07
- 특허 번호
- US05919792
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