1-Benzyloxy-4-(2-methoxyethoxy)benzene → 4-(2-Methoxyethoxy)phenol

HRID 580974노트

반응식

HRID 580974 반응식
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH2:17][O:18][CH3:19])=[CH:11][CH:10]=1)C1C=CC=CC=1>[Pd].C(O)C>[CH3:19][O:18][CH2:17][CH2:16][O:15][C:12]1[CH:13]=[CH:14][C:9]([OH:8])=[CH:10][CH:11]=1

참가 물질

4

반응물 1

HCID 133135851-Benzyloxy-4-(2-methoxyethoxy)benzene

생성물 1

HCID 133135614-(2-Methoxyethoxy)phenol수율 80.8%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of 1-(benzyloxy)-4-(2-methoxyethoxy)benzene (180 g), ethanol (2000 ml) and palladium on carbon catalyst (20 g) was stirred under an atmosphere of hydrogen, at room temperature and atmospheric pressure. After the theoretical quantity of hydrogen had been consumed, the reaction mixture was filtered. The filtrate was evaporated to give a solid which was crystallised from a mixture of ethyl acetate and n-hexane to give 4-(2-methoxyethoxy)phenol as a solid (94.7 g) m.p. 97.9° C.; microanalysis, found: C, 64.3%; H, 7.4%; C9H12O3 requires: C, 64.3%; H, 7.2%; NMR: 3.35(3H,s), 3.6(2H,m), 3.95(2H,m), 6.7(4H,m) and 8.9(1H,s); m/z 169(M+H).

후처리

  1. customAfter the theoretical quantity of hydrogen had been consumed
  2. filtrationthe reaction mixture was filtered
  3. customThe filtrate was evaporated
  4. customto give a solid which
  5. customwas crystallised from a mixture of ethyl acetate and n-hexane

출처 및 근거

ORD 기록
ord-769281acd38042f988026185e71a313c
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05919793

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