Butylamine → 2-(4-Iodophenyl)acetamide

HRID 580998노트

반응식

HRID 580998 반응식
C([NH2:5])CCC.[I:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14](Cl)=[O:15])=[CH:9][CH:8]=1>CCOCC>[I:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14]([NH2:5])=[O:15])=[CH:9][CH:8]=1

참가 물질

4

반응물 2

HCID 8007ButylamineHCID 13340573HCID 13340573, 화합물

생성물 1

HCID 130308042-(4-Iodophenyl)acetamide

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

1-Butylamine (1.83 g) was added to a solution of 4-iodophenylacetyl chloride (2.80 g) in ether (25 ml), and the reaction mixture was stirred at ambient temperature for 5 minutes. The reaction mixture was then partitioned between water (30 ml) and ethyl acetate (50 ml). The organic layer was washed with 2M aqueous hydrochloric acid (25 ml), water (30 ml), brine (25 ml), dried (MgSO4), and evaporated to give N-1-butyl, (4-iodophenyl)acetamide, as a colourless crystalline solid, (2.9 g), mp.: 100-102° C., NMR: 0.82-0.88(3H,t), 1.18-1.43(4H,m), 3.00-3.06(2H,q), 3.35(2H,s), 7.03-7.67(4H,AB), 7.97(H,bt); m/z 318 (M+H).

후처리

  1. customThe reaction mixture was then partitioned between water (30 ml) and ethyl acetate (50 ml)
  2. washThe organic layer was washed with 2M aqueous hydrochloric acid (25 ml), water (30 ml), brine (25 ml)
  3. dry with materialdried (MgSO4)
  4. customevaporated

출처 및 근거

ORD 기록
ord-31e4fb2631ad4e01a070e77db430aa63
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05919793

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