Thionyl Chloride → HCID 13340573, 화합물

HRID 580999노트

반응식

HRID 580999 반응식
S(Cl)([Cl:3])=O.[I:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][C:13]([OH:15])=O)=[CH:8][CH:7]=1>CN(C=O)C.ClCCl>[I:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][C:13]([Cl:3])=[O:15])=[CH:8][CH:7]=1

참가 물질

5

반응물 2

HCID 24386Thionyl ChlorideHCID 1372144-Iodophenylacetic acid

생성물 1

HCID 13340573HCID 13340573, 화합물

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 6344Dichloromethane용매

실험 절차

Thionyl chloride (39.53) and DMF (2 drops) were added to a solution of 4-iodophenylacetic acid (26.2 g), in dichloromethane (150 ml). The reaction mixture was stirred at ambient temperature for 18 hours and the solvent removed by evaporation to give 4-iodophenylacetyl chloride as an oil (23 g) which was purified by vacuum distillation; b.p. 118-119° C. (0.35 mmMg)

후처리

  1. customthe solvent removed by evaporation

출처 및 근거

ORD 기록
ord-17579de340d84bff8ef4873a7016403c
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05919793

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