Potassium Iodide → HCID 86754176, 화합물

HRID 581066노트

반응식

HRID 581066 반응식
BrBr.Br[CH2:4][CH2:5][O:6][C:7]1[C:16]2[O:15][CH2:14][CH2:13][O:12][C:11]=2[CH:10]=[CH:9][CH:8]=1.[C:17]1(=[O:27])[NH:21][C:20](=[O:22])[C:19]2=[CH:23][CH:24]=[CH:25][CH:26]=[C:18]12.[K].[I-].[K+]>CN(C)C=O>[O:12]1[C:11]2[CH:10]=[CH:9][CH:8]=[C:7]([O:6][CH2:5][CH2:4][N:21]3[C:17](=[O:27])[C:18]4[C:19](=[CH:23][CH:24]=[CH:25][CH:26]=4)[C:20]3=[O:22])[C:16]=2[O:15][CH2:14][CH2:13]1

참가 물질

6

반응물 4

HCID 4875Potassium IodideHCID 24408BromineHCID 27355665-(2-Bromoethoxy)-2,3-dihydro-1,4-benzodioxineHCID 24194345Phthalimide potassium salt

생성물 1

HCID 86754176HCID 86754176, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Replacement of the bromine of the compound obtained in Step A is carried out in dimethylformamide (10 ml) under an argon atmosphere in the presence of potassium phthalimide (1.5 eq.) catalysed by potassium iodide (0.07 eq.). The reaction mixture is stirred and heated at reflux for 3 hours. The residual and resulting salts are removed by filtration; the product is then precipitated in the cold by the addition of water to the filtrate. The solid formed is filtered and then dried in vacuo in the presence of phosphorus pentoxide.

후처리

  1. temperatureheated
  2. temperatureat reflux for 3 hours
  3. customThe residual and resulting salts
  4. customare removed by filtration
  5. customthe product is then precipitated in the cold by the addition of water to the filtrate
  6. customThe solid formed
  7. filtrationis filtered
  8. dry with materialdried in vacuo in the presence of phosphorus pentoxide

출처 및 근거

ORD 기록
ord-c0bd2d2f8cdd4fbd9e58c430d403aea5
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05919814

반응 노트

불러오는 중…