8-methoxy-2H-chromene → HCID 13758736, 화합물

HRID 581070노트

반응식

HRID 581070 반응식
[CH3:1][O:2][C:3]1[C:12]2[O:11][CH2:10][CH:9]=[CH:8][C:7]=2[CH:6]=[CH:5][CH:4]=1.[H][H]>C(O)(=O)C.[Pd]>[CH3:1][O:2][C:3]1[C:12]2[O:11][CH2:10][CH2:9][CH2:8][C:7]=2[CH:6]=[CH:5][CH:4]=1

참가 물질

5

반응물 2

HCID 123719428-methoxy-2H-chromeneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 13758736HCID 13758736, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 176Acetic Acid용매

실험 절차

The compound obtained in Step B (1 g:6.84 mmol) dissolved in glacial acetic acid (10 ml) is poured into the reactor of a Paar apparatus. 10% palladium on carbon (10% by weight; 100 mg), acting as catalyst, is added. The whole is then subjected to a hydrogen pressure of 45 psi for 12 hours at room temperature. After filtration, the solvent is removed under reduced pressure and then extraction is carried out with dichloromethane. The recovered organic phase, dried over magnesium sulphate, is purified after concentration over a silica column eluted with pure dichloromethane. The title product is obtained pure in the form of a yellow oil.

후처리

  1. additionis poured into the reactor of a Paar apparatus
  2. additionis added
  3. filtrationAfter filtration
  4. customthe solvent is removed under reduced pressure
  5. extractionextraction
  6. dry with materialThe recovered organic phase, dried over magnesium sulphate
  7. customis purified
  8. concentrationafter concentration over a silica column
  9. washeluted with pure dichloromethane

출처 및 근거

ORD 기록
ord-6eb18eefd2fe4e75b69526204d65328d
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05919814

반응 노트

불러오는 중…