Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-(tert-butoxycarbonyl)glycine → N-(2-Benzyloxyphenyl)-2-(N-tertiary butoxycarbonylamino)acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-(tert-butoxycarbonyl)glycine | HCID 78288 | — |
| 반응물 | 2-Benzyloxyaniline | HCID 240548 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-(2-Benzyloxyphenyl)-2-(N-tertiary butoxycarbonylamino)acetamide | HCID 10760721 | 39.3% |
반응 단계
2-Benzyloxyaniline (S1) (16.4 g), 4-dimethylamino-pyridine (11.0 g), and N-tertiarybutoxycarbonylglycine (14.4 g) were dissolved in dichloromethane. To the resulting solution, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (16.3 g) was added and stirred for 12 hours at room temperature. The reaction mixture was washed -successively with 1N HCl, saturated aqueous sodium hydrogencarbonate solution and brine, then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, obtaining 11.5 g of the compound S2 as white powder.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05919824 |
| 출처 데이터셋 | uspto-grants-1999_07 |
| ORD ID | ord-b44b8e5944b745e288b15e69b0db9131 |
| 출처 메모 | uspto-grants-1999_07 |