2-Nitrophenol → HCID 2500489, 화합물

HRID 581181노트

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HRID 581181 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[OH:10])([O-:3])=[O:2].C(=O)([O-])[O-].[K+].[K+].[CH3:17][N:18]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:19](=[O:22])[CH2:20]Br>CN(C)C=O>[CH3:17][N:18]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:19](=[O:22])[CH2:20][O:10][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[N+:1]([O-:3])=[O:2]

참가 물질

5

반응물 3

HCID 69472-NitrophenolHCID 11430Potassium CarbonateHCID 344952-Bromo-N-methyl-N-phenylacetamide

생성물 1

HCID 2500489HCID 2500489, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
67.5 °C

실험 절차

2-Nitrophenol S7 (2.8 g), anhydrous potassium carbonate (4.1 g), and N-methyl-N-phenyl-2-bromoacetamide (4.5 g) were suspended in N,N-dimethylformamide (50 ml), and the resulting suspension was stirred at 65-70° C. for 3 hours. The reaction mixture was poured into ice-water and extracted with ethyl acetate. The extract was washed with water and brine, then dried over anhydrous magnesium sulfate. The solvent was distilled off, obtaining 5.4 g of the compound S8.

후처리

  1. extractionextracted with ethyl acetate
  2. washThe extract was washed with water and brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. distillationThe solvent was distilled off

출처 및 근거

ORD 기록
ord-cb54b45bb82349408f29369222275e55
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05919824

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