Triethylamine → (R)-3-benzylpiperazin-2-one

HRID 581194노트

반응식

HRID 581194 반응식
C[O:2][C:3](=O)[C@H:4]([NH:12][CH2:13][CH2:14][NH2:15])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.C(N(CC)CC)C>C(Cl)Cl>[CH2:5]([C@H:4]1[NH:12][CH2:13][CH2:14][NH:15][C:3]1=[O:2])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

참가 물질

4

반응물 2

HCID 8471TriethylamineHCID 54002275(2R)-2-(2-aminoethylamino)-3-phenylpropionic acid methyl ester

생성물 1

HCID 16740989(R)-3-benzylpiperazin-2-one수율 63.5%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

(2R)-2-(2-Aminoethylamino)-3-phenylpropionic acid methyl ester (0.67 g; 1.49 mmol) and triethylamine (1 ml) were dissolved in methylene chloride (10 ml) and stirred for 48 hours at room temperature. The reaction mixture was evaporated and the residue was chromatographed on silica (2.5×30 cm) using a 7% solution of ammonia in ethanol/methylene chloride (1:9) as eluent to afford 0.18 g of (3R)-3-benzylpiperazin-2-one.

후처리

  1. customThe reaction mixture was evaporated
  2. customthe residue was chromatographed on silica (2.5×30 cm)

출처 및 근거

ORD 기록
ord-fcd0501296b94eeb9008f2a96e14f9e4
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05919777

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