Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → (6-Chloro-pyrimidin-4-yl)-[3-(4-methyl-piperazin-1-yl)-propyl]-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 4,6-Dichloropyrimidine | HCID 70943 | — |
| 반응물 | 1-(3-Aminopropyl)-4-methylpiperazine | HCID 78328 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | (6-Chloro-pyrimidin-4-yl)-[3-(4-methyl-piperazin-1-yl)-propyl]-amine | HCID 118024570 | 51.9% |
반응 단계
To a solution of 4,6-dichloro-pyrimidine (1.5 g, 10 mmol) and DIPEA (1.55 g, 12 mmol) in iPrOH (50 mL) was added a solution of 3-(4-methyl-piperazin-1-yl)-propylamine (1.73 g, 11 mmol) at room temperature. The resulting mixture was stirred at room temperature for 2 hours. Water was added and the mixture was extracted with DCM. The combined extracts were washed with brine, dried over anhydrous Na2SO4, and concentrated to afford the title compound (1.4 g, 51%), which was used directly in the next step without further purification. MS (ESI): 270 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09434697B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-f2185db81fe14e08b1f93afe3b2633b1 |
| 출처 메모 | uspto-grants-2016_09 |