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2-(Trifluoromethyl)thiophene → 4-Chloro-6-methoxy-2-(5-trifluoromethyl-2-thienyl)pyrimidine

HRID 581811
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인쇄 미리보기

반응식

HRID 581811 반응식
[F:1][C:2]([F:9])([F:8])[C:3]1[S:4][CH:5]=[CH:6][CH:7]=1.C([Li])CCC.Cl[C:16]1[N:21]=[C:20]([Cl:22])[CH:19]=[C:18]([O:23][CH3:24])[N:17]=1>C(OCC)C.CCCCCC>[Cl:22][C:20]1[CH:19]=[C:18]([O:23][CH3:24])[N:17]=[C:16]([C:5]2[S:4][C:3]([C:2]([F:9])([F:8])[F:1])=[CH:7][CH:6]=2)[N:21]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 27607852-(Trifluoromethyl)thiopheneHCID 38245092,4-Dichloro-6-methoxypyrimidineHCID 178418339Butyllithium

생성물 1

HCID 540993474-Chloro-6-methoxy-2-(5-trifluoromethyl-2-thienyl)pyrimidine

시약·촉매·용매 2

HCID 3283Diethyl Ether용매2회HCID 8058Hexane
용매

반응 조건

온도
-40 °C

실험 절차

2.05 g 2-Trifluoromethylthiophene in 20 mL diethylether are treated with 8.2 mL of a 1.6 M solution of n-butyllithium in hexane at -70° C. After 30 minutes the mixture is warmed to -40° C. and added dropwise to a solution of 2,4-dichloro-6-methoxypyrimidine in 20 mL of ether, which is kept at 0° C. The mixture is allowed to reach room temperature, is washed with water and 0.24 g of the product are isolated as an oil after flash chromatography.

후처리

  1. customis kept at 0° C
  2. customto reach room temperature
  3. washis washed with water and 0.24 g of the product
  4. customare isolated as an oil after flash chromatography

출처 및 근거

ORD 기록
ord-347e73111655408daa4eaa430869fbeb
출처 데이터셋
uspto-grants-1999_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05922726

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