Water → 2-Chloro-6-methyl-4-(1-methyl-3-trifluoromethyl-5-pyrazolyloxy)pyrimidine

HRID 581812노트

반응식

HRID 581812 반응식
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[C:4]([CH3:9])[N:3]=1.[CH3:10][N:11]1[C:15](=[O:16])[CH2:14][C:13]([C:17]([F:20])([F:19])[F:18])=[N:12]1.C(=O)([O-])[O-].[K+].[K+].O>C(#N)C>[Cl:1][C:2]1[N:7]=[C:6]([O:16][C:15]2[N:11]([CH3:10])[N:12]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:14]=2)[CH:5]=[C:4]([CH3:9])[N:3]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 794712,4-Dichloro-6-methylpyrimidineHCID 5185661-Methyl-3-trifluoromethyl-2-pyrazolin-5-one

생성물 1

HCID 537715222-Chloro-6-methyl-4-(1-methyl-3-trifluoromethyl-5-pyrazolyloxy)pyrimidine수율 68%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

5 g 2,4-Dichloro-6-methylpyrimidine, 5.3 g 1-methyl-3-trifluoromethyl-2-pyrazolin-5-one, and 6.2 g potassium carbonate in 100 mL dry acetonitrile are refluxed for 2 hours. The mixture is poured into water, extracted with ethyl acetate and chromatographed to give 6.1 g of the title compound (m.p. 65° C.)

후처리

  1. extractionextracted with ethyl acetate
  2. customchromatographed

출처 및 근거

ORD 기록
ord-890e4213e28f46a291e69de790d9aa1f
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05922726

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