Pyridine → HCID 86754218, 화합물

반응식

[CH:1]1([CH2:6][OH:7])[CH2:5][CH:4]=[CH:3][CH2:2]1.[C:8]1(C)[CH:13]=[CH:12][C:11]([S:14](Cl)(=[O:16])=[O:15])=[CH:10][CH:9]=1.N1C=CC=C[CH:20]=1>>[C:10]1([CH3:20])[C:11]([S:14]([O:7][CH2:6][CH:1]2[CH2:5][CH:4]=[CH:3][CH2:2]2)(=[O:15])=[O:16])=[CH:12][CH:13]=[CH:8][CH:9]=1

참가 물질

반응물 3

HCID 1049Pyridine

HCID 73974-Toluenesulfonyl chloride

HCID 1514122Cyclopent-3-en-1-ylmethanol

생성물 1

HCID 86754218HCID 86754218, 화합물수율 83.2%

실험 절차

A mixture of (cyclopent-3-en-1-yl)methanol (1.96 g, 20 mmol) and para-toluenesulfonylchloride (3.81 g, 20 mmol) were stirred at room temperature for 2 hrs in pyridine (30 ml). After the concentration of pyridine, the reaction residues were extracted with dichloromethane, washed 1N HCl, dried with MgSO4, concentrated and separated by the column chromatography to give the desirable product (4.20 g).

후처리

extractionAfter the concentration of pyridine, the reaction residues were extracted with dichloromethane
washwashed 1N HCl
dry with materialdried with MgSO4
concentrationconcentrated
customseparated by the column chromatography

출처 및 근거

ORD 기록: ord-82c9268c62c04cfea2182649ff42a46c
출처 데이터셋: uspto-grants-1999_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05922727

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