Pyridine → HCID 88084319, 화합물

반응식

[C:1]1([CH2:6][OH:7])[CH2:5][CH2:4][CH2:3][CH:2]=1.[C:8]1(C)[CH:13]=[CH:12][C:11]([S:14](Cl)(=[O:16])=[O:15])=[CH:10][CH:9]=1.N1C=CC=C[CH:20]=1>>[C:10]1([CH3:20])[C:11]([S:14]([O:7][CH2:6][C:1]2[CH2:5][CH2:4][CH2:3][CH:2]=2)(=[O:15])=[O:16])=[CH:12][CH:13]=[CH:8][CH:9]=1

참가 물질

반응물 3

HCID 1049Pyridine

HCID 73974-Toluenesulfonyl chloride

HCID 110515841-Cyclopentene-1-methanol

생성물 1

HCID 88084319HCID 88084319, 화합물수율 89.6%

실험 절차

A mixture of (cyclopent-1-en-1-yl)methanol (1.96 g, 20 mmol) and para-toluenesulfonylchloride (3.81 g, 20 mmol) were stirred at room temperature for 2 hrs in pyridine (30 ml). After the concentration of pyridine, the reaction residues were extracted with dichloromethane, washed 1N HCl, dried with MgSO4, concentrated and separated by the column chromatography to give the desirable product (4.52 g).

후처리

extractionAfter the concentration of pyridine, the reaction residues were extracted with dichloromethane
washwashed 1N HCl
dry with materialdried with MgSO4
concentrationconcentrated
customseparated by the column chromatography

출처 및 근거

ORD 기록: ord-752adc126ed945b7b6087687603e2034
출처 데이터셋: uspto-grants-1999_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05922727

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