5-Ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione → 1-{[3,4-Di(hydroxymethyl)cyclopent-1-en-1-yl]methyl}-5-ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione

HRID 581875

반응식

HRID 581875 반응식
[CH2:1]([C:3]1[C:4](=[O:19])[NH:5][C:6](=[O:18])[NH:7][C:8]=1[O:9][C:10]1[CH:15]=[C:14]([CH3:16])[CH:13]=[C:12]([CH3:17])[CH:11]=1)[CH3:2].[Si]([O:27][CH2:28][CH:29]1[CH:33]([CH2:34][O:35][Si](C(C)(C)C)(C)C)[CH2:32][C:31]([CH2:43]Br)=[CH:30]1)(C(C)(C)C)(C)C>>[OH:27][CH2:28][CH:29]1[CH:33]([CH2:34][OH:35])[CH2:32][C:31]([CH2:43][N:7]2[C:8]([O:9][C:10]3[CH:11]=[C:12]([CH3:17])[CH:13]=[C:14]([CH3:16])[CH:15]=3)=[C:3]([CH2:1][CH3:2])[C:4](=[O:19])[NH:5][C:6]2=[O:18])=[CH:30]1

참가 물질

3

반응물 2

HCID 109232665-Ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedioneHCID 54350482[3,4-Di(t-butyldimethylsilyloxymethyl)cyclopent-1-en-1-yl]methyl bromide

생성물 1

HCID 537707861-{[3,4-Di(hydroxymethyl)cyclopent-1-en-1-yl]methyl}-5-ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione수율 17.9%

실험 절차

5-Ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione and [3,4-di(t-butyldimethylsilyloxymethyl)cyclopent-1-en-1-yl]methyl bromide were reacted by the same method with example 28 to obtain the titled compound (42 mg).

출처 및 근거

ORD 기록
ord-1af4f80f76084b64ab9733192e2b0430
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05922727

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