5-Isopropyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione → 1-{[3,4-Di(hydroxymethyl)cyclopent-1-en-1-yl]methyl}-5-isopropyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione

HRID 581876

반응식

HRID 581876 반응식
[CH:1]([C:4]1[C:5](=[O:20])[NH:6][C:7](=[O:19])[NH:8][C:9]=1[O:10][C:11]1[CH:16]=[C:15]([CH3:17])[CH:14]=[C:13]([CH3:18])[CH:12]=1)([CH3:3])[CH3:2].[Si]([O:28][CH2:29][CH:30]1[CH:34]([CH2:35][O:36][Si](C(C)(C)C)(C)C)[CH2:33][C:32]([CH2:44]Br)=[CH:31]1)(C(C)(C)C)(C)C>>[OH:28][CH2:29][CH:30]1[CH:34]([CH2:35][OH:36])[CH2:33][C:32]([CH2:44][N:8]2[C:9]([O:10][C:11]3[CH:12]=[C:13]([CH3:18])[CH:14]=[C:15]([CH3:17])[CH:16]=3)=[C:4]([CH:1]([CH3:3])[CH3:2])[C:5](=[O:20])[NH:6][C:7]2=[O:19])=[CH:31]1

참가 물질

3

반응물 2

HCID 222565785-Isopropyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedioneHCID 54350482[3,4-Di(t-butyldimethylsilyloxymethyl)cyclopent-1-en-1-yl]methyl bromide

생성물 1

HCID 536929791-{[3,4-Di(hydroxymethyl)cyclopent-1-en-1-yl]methyl}-5-isopropyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione수율 17.5%

실험 절차

5-Isopropyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione and [3,4-di(t-butyldimethylsilyloxymethyl)cyclopent-1-en-1-yl]methyl bromide were reacted by the same method with example 28 to obtain the titled compound (48 mg).

출처 및 근거

ORD 기록
ord-48fc8c4fda3143ad87a132744d09c432
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05922727

연결된 노트

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