HCID 12130786, 화합물 → 3-(Pyrimidin-4-yl)aniline

HRID 581918노트

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HRID 581918 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][N:13]=[CH:12][N:11]=2)[CH:7]=[CH:8][CH:9]=1)([O-])=O>CO.C1COCC1.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][N:13]=[CH:12][N:11]=2)[CH:7]=[CH:8][CH:9]=1

참가 물질

5

반응물 1

HCID 12130786HCID 12130786, 화합물

생성물 1

HCID 124561713-(Pyrimidin-4-yl)aniline수율 96.1%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

To a suspension of (57) (6.3 g, 31 mmol) in a mixture of MeOH (60 ml) and THF (30 ml) was added 5% palladium on activated carbon (300 mg) and the mixture was hydrogenated at ambient pressure for 1 hr. The mixture was filtered and concentrated under reduced pressure. The residue was purified by column-chromatography on silica gel using a mixture of hexane and ethylacetate (3:1) as the eluent to give (58) (5.1 g, 96%).

후처리

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated under reduced pressure
  3. customThe residue was purified by column-chromatography on silica gel using
  4. additiona mixture of hexane and ethylacetate (3:1) as the eluent

출처 및 근거

ORD 기록
ord-a5069e84f2b04ef59b17fbd933c68f11
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05922725

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