O-Methylhydroxylamine hydrochloride → HCID 87417072, 화합물

HRID 581922노트

반응식

HRID 581922 반응식
[CH:1]([C:3]1[CH:23]=[CH:22][C:6]2[N:7]([C:10]3[CH:15]=[CH:14][CH:13]=[C:12]([C:16]4[CH:21]=[CH:20][N:19]=[CH:18][N:17]=4)[CH:11]=3)[CH:8]=[N:9][C:5]=2[CH:4]=1)=O.[NH2:24][O:25][CH3:26].Cl>>[CH3:26][O:25][N:24]=[CH:1][C:3]1[CH:23]=[CH:22][C:6]2[N:7]([C:10]3[CH:15]=[CH:14][CH:13]=[C:12]([C:16]4[CH:21]=[CH:20][N:19]=[CH:18][N:17]=4)[CH:11]=3)[CH:8]=[N:9][C:5]=2[CH:4]=1

참가 물질

3

반응물 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 539508245-Formyl-1-(3-(4-pyrimidyl)phenyl)benzimidazole

생성물 1

HCID 87417072HCID 87417072, 화합물수율 28.1%

실험 절차

was synthesized as described in Example 22 but using (62) (200 mg, 0.66 mmol) instead of (55) and NH2OMe.HCl (250 mg, 2.0 mmol). The reaction gave (64) (61 mg, 28%). Mp. 180-182° C.

후처리

  1. customwas synthesized

출처 및 근거

ORD 기록
ord-3e944dcefd484bb68d56dd7699de8040
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05922725

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