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Water → N-(3-(1-Imidazolyl)phenyl)-2-amino-4-(3-furanyl)aniline

HRID 581944
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HRID 581944 반응식
[N:1]1([C:6]2[CH:7]=[C:8]([NH:12][C:13]3[CH:18]=[CH:17][C:16](C4OC=CC=4)=[CH:15][C:14]=3[N+:24]([O-])=O)[CH:9]=[CH:10][CH:11]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[Cl-].[NH4+].[OH2:29].O.O.O.O.O.O.O.O.[S-2].[Na+].[Na+].O>C(O)C>[N:1]1([C:6]2[CH:7]=[C:8]([NH:12][C:13]3[CH:18]=[CH:17][C:16]([C:6]4[CH:11]=[CH:10][O:29][CH:7]=4)=[CH:15][C:14]=3[NH2:24])[CH:9]=[CH:10][CH:11]=2)[CH:5]=[CH:4][N:3]=[CH:2]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 962WaterHCID 25517Ammonium ChlorideHCID 73972Sodium sulfide nonahydrateHCID 54198063HCID 54198063, 화합물

생성물 1

HCID 15521704N-(3-(1-Imidazolyl)phenyl)-2-amino-4-(3-furanyl)aniline수율 146.3%

시약·촉매·용매 1

HCID 702Ethanol
용매

실험 절차

To a solution of 7c from Example 11 (13 g, 37.6 mmol) in ethanol (25 ml) is added ammonium chloride (6.03 g, 113 mmol) and sodium sulfide nonahydrate (27.05 g, 113 mmol). The mixture is heated to reflux for 1 hour. After cooling the mixture is poured into 700 ml of water. The product is filtered off, washed with water and air-dried to yield 8c (8.7 g, 73%). Mp 188-189° C.

후처리

  1. temperatureThe mixture is heated
  2. temperatureto reflux for 1 hour
  3. temperatureAfter cooling the mixture
  4. filtrationThe product is filtered off
  5. washwashed with water
  6. customair-dried

출처 및 근거

ORD 기록
ord-316d9a20b23b413c9475cf406668694f
출처 데이터셋
uspto-grants-1999_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05922724

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