Dopac → Methyl 3,4-dihydroxyphenylacetate

HRID 582047

반응식

HRID 582047 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=[O:11])[CH:5]=[CH:6][C:7]=1[OH:8].S(=O)(=O)(O)O.[CH3:18]O>>[OH:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([O:12][CH3:18])=[O:11])[CH:5]=[CH:6][C:7]=1[OH:8]

참가 물질

4

반응물 3

HCID 547DopacHCID 887MethanolHCID 1118Sulfuric Acid

생성물 1

HCID 11008556Methyl 3,4-dihydroxyphenylacetate

실험 절차

A mixture of 3,4-dihydroxyphenylacetic acid (10.0 g) and concentrated sulphuric acid (0.5 ml ) in methanol (70 ml) was heated under reflux for 16 hours. The mixture was concentrated, water was added and the mixture was neutralised to pH7 using sodium carbonate. The cloudy solution obtained was extracted with dichloromethane (200 ml), dried (Na2SO4) and evaporated to give a yellow gum (7.64 g). LRMS m/z=183(m+1)+.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 16 hours
  3. concentrationThe mixture was concentrated
  4. additionwater was added
  5. customThe cloudy solution obtained
  6. extractionwas extracted with dichloromethane (200 ml)
  7. dry with materialdried (Na2SO4)
  8. customevaporated

출처 및 근거

ORD 기록
ord-eccd76d2b243402faaa07ef69d3c5c89
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05922747

연결된 노트

불러오는 중…