(E)-N-[2-(6-methoxyindan-1-ylidene)ethyl]acetamide → N-[2-(5-Methoxy-1H-inden-3-yl)ethyl]acetamide

HRID 582210노트

반응식

HRID 582210 반응식
[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([CH2:7][CH2:8]/[C:9]/2=[CH:12]\[CH2:13][NH:14][C:15](=[O:17])[CH3:16])=[CH:5][CH:4]=1>FC(F)(F)C(O)=O.O1CCCC1.O>[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6](=[CH:5][CH:4]=1)[CH2:7][CH:8]=[C:9]2[CH2:12][CH2:13][NH:14][C:15](=[O:17])[CH3:16]

참가 물질

5

반응물 1

HCID 59957023(E)-N-[2-(6-methoxyindan-1-ylidene)ethyl]acetamide

생성물 1

HCID 54016815N-[2-(5-Methoxy-1H-inden-3-yl)ethyl]acetamide수율 90.1%

시약·촉매·용매 3

HCID 962Water용매HCID 6422Trifluoroacetic acid용매HCID 8028Tetrahydrofuran용매

실험 절차

The (E)-N-[2-(6-methoxyindan-1-ylidene)ethyl]-acetamide (1.0 g, 4.32 mmol) thus obtained was dissolved in trifluoroacetic acid(6 ml)-tetrahydrofuran(6 ml) and the solution was refluxed for 1.5 hours. This reaction mixture was poured in water and extracted with ethyl acetate. The extract was washed serially with saturated saline and water and dried over anhydrous magnesium sulfate and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate-methanol=96:4) to provide the title compound (yield 0.9 g, 90%).

후처리

  1. temperaturethe solution was refluxed for 1.5 hours
  2. extractionextracted with ethyl acetate
  3. washThe extract was washed serially with saturated saline and water
  4. dry with materialdried over anhydrous magnesium sulfate
  5. distillationthe solvent was distilled off under reduced pressure
  6. customThe residue was purified by silica gel column chromatography (ethyl acetate-methanol=96:4)

출처 및 근거

ORD 기록
ord-4565cd77d32543e7903de635a35c357a
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05922771

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