5-Iodo-2-nitrobenzotrifluoride → 1-Nitro-2,3-bis(trifluoromethyl)benzene

반응식

[N+:1]([C:4]1[CH:9]=[CH:8][C:7](I)=[CH:6][C:5]=1[C:11]([F:14])([F:13])[F:12])([O-:3])=[O:2].[F:15][C:16]([Cu])([F:18])[F:17]>>[F:15][C:16]([C:6]1[C:5]([C:11]([F:14])([F:13])[F:12])=[C:4]([N+:1]([O-:3])=[O:2])[CH:9]=[CH:8][CH:7]=1)([F:18])[F:17]

참가 물질

반응물 2

HCID 111309085-Iodo-2-nitrobenzotrifluoride

HCID 178506351HCID 178506351, 화합물

생성물 1

HCID 151030541-Nitro-2,3-bis(trifluoromethyl)benzene

실험 절차

A process for the synthesis of the compound of the formula ##STR18## which comprises the steps of a) nitration of compound 2 of the formula ##STR19## to afford compound 3 of the formula ##STR20## b) reaction of compound 3 with trifluoromethyl copper to afford compound 4 of the formula ##STR21## c) displacement of the nitro of compound 4 to afford compound 5 of the formula ##STR22## d) which is subsequently hydrolyzed and decarboxylated to afford compound 6.

출처 및 근거

ORD 기록: ord-0397e95eb82e45259cf3191e4d9f54da
출처 데이터셋: uspto-grants-1999_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05922906

반응 노트

불러오는 중…