Aniline → N-Phenyl-2-furancarboxamide

HRID 582440

반응식

HRID 582440 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.[O:15]1[CH:19]=[CH:18][CH:17]=[C:16]1[C:20](Cl)=[O:21]>ClCCl>[C:2]1([NH:1][C:20]([C:16]2[O:15][CH:19]=[CH:18][CH:17]=2)=[O:21])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 6115AnilineHCID 8471TriethylamineHCID 682422-Furancarbonyl chloride

생성물 1

HCID 220406N-Phenyl-2-furancarboxamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
-10 °C

실험 절차

N-phenyl furamide was prepared by adding to a mixture of aniline (23.3 g; 250 mmol) and triethylamine (25.3 g; 250 mmol) in dichloromethane slowly 32.6 g (250 mmol) of 2-furoyl chloride, while maintaining the temperature at -10° C. The product obtained was washed with diluted hydrochloric acid and water, dried with magnesium sulphate and evaporated. The product so obtained was than triturated with hexane and filtered. 39.3 g (84% yield of product was recovered.

후처리

  1. customThe product obtained
  2. washwas washed with diluted hydrochloric acid and water
  3. dry with materialdried with magnesium sulphate
  4. customevaporated
  5. customThe product so obtained
  6. customthan triturated with hexane
  7. filtrationfiltered

출처 및 근거

ORD 기록
ord-ec294cbabf8b4576be6a8b4d93a811ec
출처 데이터셋
uspto-grants-1999_07
특허 번호
US05925152

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