Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
8-(2-(4-Hydroxy-6-oxooxan-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2-methylbutanoate → Lovastatin
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 8-(2-(4-Hydroxy-6-oxooxan-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2-methylbutanoate | HCID 3962 | — |
| 반응물 | Lovastatin | HCID 53232 | — |
| 생성물 | Lovastatin | HCID 53232 | — |
| 생성물 | Lovastatin Acid | HCID 64727 | — |
반응 단계
Lovastatin is chemically represented as [1S-[1α(R*),3α,7β,8β(2S*,4S*),8αβ]]-2-methylbutanoic acid 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester, and strains producing the compound also produce an acid form of lovastatin, i.e., mevinolinic acid, which is converted into lovastatin(mevinolin) as a lactone form in the course of isolation and recovery.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05925551 |
| 출처 데이터셋 | uspto-grants-1999_07 |
| ORD ID | ord-9bbb0eec042f4c9192f3c1a2906d5c11 |
| 출처 메모 | uspto-grants-1999_07 |