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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 582457생성일: 2026년 10월 26일

8-(2-(4-Hydroxy-6-oxooxan-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2-methylbutanoate → Lovastatin

https://huagongshe.com/reaction/582457

반응식

참여 물질

역할이름HCID투입량
반응물8-(2-(4-Hydroxy-6-oxooxan-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2-methylbutanoateHCID 3962—
반응물LovastatinHCID 53232—
생성물LovastatinHCID 53232—
생성물Lovastatin AcidHCID 64727—

반응 단계

Lovastatin is chemically represented as [1S-[1α(R*),3α,7β,8β(2S*,4S*),8αβ]]-2-methylbutanoic acid 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester, and strains producing the compound also produce an acid form of lovastatin, i.e., mevinolinic acid, which is converted into lovastatin(mevinolin) as a lactone form in the course of isolation and recovery.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US05925551
출처 데이터셋uspto-grants-1999_07
ORD IDord-9bbb0eec042f4c9192f3c1a2906d5c11
출처 메모uspto-grants-1999_07