Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetic acid → TFA acetonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | 3-Oxo-2-[1(R)-methyl-2(pyridin-2-yl)ethyl]-2,3-dihydro-1-H-isoindole-5-carbonyl-2(S)phenylsulfonylamino-beta-alanine t-butyl ester | HCID 86754267 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | TFA acetonitrile | HCID 21924481 | — |
| 생성물 | Trifluoroacetic acid water | HCID 22392675 | — |
| 생성물 | 3-Oxo-2-[1(R)-methyl-2(pyridin-2-yl)ethyl]-2,3-dihydro-1-H-isoindole-5-carbonyl-2(S)phenylsulfonylamino-beta-alanine | HCID 86754266 | — |
반응 단계
A CH2Cl2 solution (20 mL) of 7-7 (44 mg, 0.074 mmol) and TFA (4 mL) was stirred under ambient conditions for 5 h and then concentrated. The residue was azeotroped with toluene (3×25 mL) to give a solid which was purified by HPLC using a VYDAC C18 semiprep column with gradient elution [95:5 (99.9:0.1 H2O/TFA)/(99.9:0.1 CH3CN/TFA)→50:50 (99.9:1 H2O/TFA) (99.9:1 CH3CN/TFA) 60 min] to provide 7-8 as a colorless solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05925655 |
| 출처 데이터셋 | uspto-grants-1999_07 |
| ORD ID | ord-c25231d2a5f7441f9d9c6ef2c5c1ddf6 |
| 출처 메모 | uspto-grants-1999_07 |