Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 582776생성일: 2026년 10월 25일
Sulfuric Acid → 2-[5-(2,6-Dimethoxyphenyl)-1-[4-[N-methyl-N-(3-dimethylaminopropyl)carbamoyl]-2-isopropylphenyl]-3-pyrazolylcarbonylamino]-2-adamantanecarboxylic acid hydrogen sulphate
https://huagongshe.com/reaction/582776
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | SR142948A | HCID 5311451 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2-[5-(2,6-Dimethoxyphenyl)-1-[4-[N-methyl-N-(3-dimethylaminopropyl)carbamoyl]-2-isopropylphenyl]-3-pyrazolylcarbonylamino]-2-adamantanecarboxylic acid hydrogen sulphate | HCID 70246179 | 94.5% |
반응 단계
0.5 g of the compound obtained in EXAMPLE 1' is added to a solution of 0.08 g of H2SO4 in 5 ml of MeOH, this solution is poured into 150 ml of ether cooled to 5° C., and the precipitate formed is drained. 0.54 g of the expected product is obtained. After recrystallization in water, m.p.=212° C. (dec.). After recrystallization in 2-isopropanol, m.p.=263° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05925661 |
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| 출처 데이터셋 | uspto-grants-1999_07 |
|---|
| ORD ID | ord-6743dd7029a74400a67f9515d89c49fc |
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| 출처 메모 | uspto-grants-1999_07 |
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